関西学院大学 生命環境学部 生命医科学科
腫瘍細胞生物学研究室 Sawada Lab
英文原著論文 #co-first authors, *corresponding authors
Kojima D#, Sawada M#, Ishimaru T, Ito N, Tateyama S, Adachi K, Kawaguchi H, Satake N, Herranz-Pérez V, García-Verdugo JM, Hirose Y, Ohno N, Kaneko N*, Sawamoto K*: Cytoarchitecture of neurogenic niche and neuroblast clusters in the postnatal microminipig brain.
Stem Cell Reports 21: 102893, 2026.
Wakayama T#, Miyake M#, Ito Y*, Oya N, Sato H, Sawada M, Sawamoto K, Kamijima M: Chronic inhalation exposure to 0.5 ppm of 2-ethyl-1-hexanol induces histopathological changes in olfactory, respiratory, and skin tissue of mice.
Journal of Occupational Health online uiag016, 2026.
Takemura S#, Kawase K#, Wolbeck L#, Nakamura Y#, Matsumoto M, Jinnou H, Tahara A, Sawada M, Kubota Y, Herranz-Pérez V, García-Verdugo JM, Ishibashi N, Gallo V, Ohno N, Khodosevich K, Sawamoto K*.
Transformation of radial glia into postnatal neural stem cells depends on birth.
Cell Reports 44:116029, 2025.
Sawada M#, Nakajima C#, Umeda E, Takagi Y, Nakashima N,Vepřek NA, Küllmer F, Nasufović V, Arndt HD, Trauner D, Igarashi M, SawamotoK*: Time-lapse super-resolution imaging and optical manipulation of growth conesin elongating axons and migrating neurons.
Bio-protocol 15: e5251, 2025.
Kawase K#, Nakamura Y#, Wolbeck L#, Takemura S#, Zaitsu K, Ando T, Jinnou H, Sawada M, Nakajima C, Rydbirk R, Gokenya S, Ito A, Fujiyama H, Saito A, Iguchi A, Kratimenos P, Ishibashi N, Gallo V, Iwata O, Saitoh S, Khodosevich K,Sawamoto K*: Significance of birth in the maintenance of quiescent neural stem cells.
Science Advances 11: eadn6377, 2025.
Ogino T, Agetsuma M, Sawada M, Inada H, Nabekura J, Sawamoto K*: Astrocytic activation increases blood flow in the adult olfactory bulb.
Molecular Brain 17: 52, 2024.
Ogino T#, Saito A#, Sawada M, Takemura S, Nagase J, Kawase H, Inada H, Herranz-Pérez V, Mukouyama Y, Ema M, García-Verdugo JM, Nabekura J, Sawamoto K*:Neuronal migration depends on blood flow in the adult brain.
eLife 13: RP99502, 2024.
Matsumoto M, Matsushita K, Hane M, Wen C, Kurematsu C, Ota H, Nguyen HB,Thai TQ, Herranz-Pérez V, Sawada M, Fujimoto K, García-Verdugo JM, KimuraKD, Seki T, Sato C, Ohno N, Sawamoto K*: Neuraminidase inhibition promotes the collective migration of neurons and recovery of brain function.
EMBO Molecular Medicine 16: 1228, 2024.
Nakajima C#, Sawada M#, Umeda E, Takagi Y, Nakashima N,Kuboyama K, Kaneko N, Yamamoto S, Nakamura H, Shimada N, Nakamura K,Matsuno K, Uesugi S, Vepřek NA, Küllmer F, Nasufović V, Uchiyama H, NakadaM, Otsuka Y, Ito Y, Herranz-Pérez V, García-Verdugo JM, Ohno N, Arndt HD,Trauner D, Tabata Y, Igarashi M, Sawamoto K*: Identification of the growth coneas a probe and driver of neuronal migration in the injured brain.
Nature Communications 15: 1877, 2024.
Sawada M, Hamaguchi A, Mano N, Yoshida Y, Uemura A, Sawamoto K*: PlexinD1 signaling controls domain-specific dendritic development in newbornneurons in the postnatal olfactory bulb.
Frontiers in Neuroscience 17: 1143130, 2023.
Wen C*, Matsumoto M, Sawada M, Sawamoto K, Kimura KD: Seg2Link: anefficient and versatile solution for semi-automatic cell segmentation in 3D image stacks.
Scientific Reports 13: 7109, 2023.
Ieda N*, Sawada M, Oguchi R, Itoh M, Hirakata S, Saitoh D, Nakao A, Kawaguchi M, Sawamoto K, Yoshihara T, Mori Y, Nakagawa H*: An Optochemical Oxygen Scavenger Enabling Spatiotemporal Control of Hypoxia.
Angewandte Chemie International Edition 16: e202217585, 2023.
Tsuboi Y, Ito A, Otsuka T, Murakami H, Sawada M*, Sawamoto K*: Habilitation Improves Mouse Gait Development Following Neonatal Brain Injury.
Progress in Rehabilitation Medicine 7: 20220061, 2022.
Kurematsu C, Sawada M, Ohmuraya M, Tanaka M, Kuboyama K, Ogino T, Matsumoto M, Oishi H, Inada H, Ishido Y, Sakakibara Y, Nguyen HB, Thai TQ, Kohsaka S, Ohno N, Yamada MK, Asai M, Sokabe M, Nabekura J, Asano K, Tanaka M, Sawamoto K*: Synaptic pruning of murine adult-born neurons by microglia depends on phosphatidylserine.
Journal of Experimental Medicine 219: e20202304, 2022.
Sawada M, Matsumoto M, Narita K, Kumamoto N, Ugawa S, Takeda S, Sawamoto K*: In vitro time-lapse imaging of primary cilium in migrating neuroblasts.
Bio-protocol 10: e3823, 2020.
Matsumoto M#, Sawada M#, García-González D, Herranz-Pérez V, OginoT, Nguyen HB, Thai TQ, Narita K, Kumamoto N, Ugawa S, Saito Y, Takeda S, Kaneko N, Khodosevich K, Monyer H, García-Verdugo JM, Ohno N, Sawamoto K*: Dynamic changes in ultrastructure of the primary cilium in migrating neuroblasts in the postnatal brain.
Journal of Neuroscience 39: 9967-9988, 2019.
Aoyagi Y, Hibi T, Kimori Y, Sawada M, Kawakami R, Sawamoto K, Nemoto T*: Heterogeneous distribution of doublecortin-expressing cells surrounding the rostral migratory stream in the juvenile mouse.
Journal of Comparative Neurology 526: 2631-2646, 2018.
Fujikake K#, Sawada M#, Hikita T, Seto Y, Kaneko N, Herranz-Pérez V, Dohi N, Homma N, Osaga S, Yanagawa Y, Akaike T, García-Verdugo JM, Hattori M, Sobue K, Sawamoto K*: Detachment of chain-forming new neurons by Fyn-mediated control of cell-cell adhesion in the postnatal brain.
Journal of Neuroscience 38: 4598-4609, 2018.
Sawada M, Ohno N, Kawaguchi M, Huang S, Hikita T, Sakurai Y, Nguyen HB, Thai TQ, Ishido Y, Yoshida Y, Nakagawa H, Uemura A, Sawamoto K*: PlexinD1 signaling controls morphological changes and migration termination in newborn neurons.
EMBO Journal 37: e97404, 2018.
Jinnou H, Sawada M, Kawase K, Kaneko N, Herranz-Pérez V, Miyamoto T, Kawaue T, Miyata T, Tabata Y, Akaike T, García-Verdugo JM, Ajioka I, Saitoh S, Sawamoto K*: Radial glial fibers promote neuronal migration and functional recovery after neonatal brain injury.
Cell Stem Cell 22: 128-137, 2018.
Takagishi M*, Sawada M, Ohata S, Asai N, Enomoto A, Takahashi K, Weng L, Ushida K, Ara H, Matsui S, Kaibuchi K, Sawamoto K, Takahashi M*: Daple coordinates planar polarized microtubule dynamics in ependymal cells and contributes to hydrocephalus.
Cell Reports 20: 960-972, 2017.
Miyake M, Ito Y*, Sawada M, Sakai K, Suzuki H, Sakamoto T, Sawamoto K, Kamijima M*: Subchronic inhalation exposure to 2-ethyl-1-hexanol impairs the mouse olfactory bulb via injury and subsequent repair of the nasal olfactory epithelium.
Archives in Toxicology 90: 1949-1958, 2016.
Ogino T, Sawada M, Takase H, Nakai C, Herranz-Pérez V, Cebrián-Silla A, Kaneko N, García-Verdugo JM, Sawamoto K*: Characterization of multiciliated ependymal cells that emerge in the neurogenic niche of the aged zebrafish brain.
Journal of Comparative Neurology 524: 2982-2992, 2016.
Hirota Y#, Sawada M#, Huang SH#, Ogino T, Ohata S, Kubo A, Sawamoto K*: Roles of Wnt signaling in the neurogenic niche of the adult mouse ventricular-subventricular zone.
Neurochemical Research 41: 222-230, 2016.
Yamagishi S*, Yamada K, Sawada M, Nakano S, Mori N, Sawamoto K*, Sato K: Netrin-5 is highly expressed in neurogenic regions of the adult brain.
Frontiers in Cellular Neuroscience 9: 146, 2015.
Ajioka I#*, Jinnou H#, Okada K, Sawada M, Saitoh S, Sawamoto K*: Enhancement of neuroblast migration into the injured cerebral cortex using laminin-containing porous sponge.
Tissue Engineering Part A 21: 193-201, 2015.
Ota H#, Hikita T#, Sawada M#, Nishioka T, Matsumoto M, Komura M, Ohno A, Kamiya Y, Miyamoto T, Asai N, Enomoto A, Takahashi M, Kaibuchi K, Sobue K, Sawamoto K*: Speed control for neuronal migration in the postnatal brain by Gmip-mediated local inactivation of RhoA.
Nature Communications 5: 4532, 2014.
Hikita T, Ohno A, Sawada M, Ota H, Sawamoto K*: Rac1-mediated indentation of resting neurons promotes the chain migration of new neurons in the rostral migratory stream of postnatal mouse brain.
Journal of Neurochemistry 128: 790-797, 2014.
Magi S, Shitara T, Takemoto Y, Sawada M, Kitagawa M, Tashiro E, Takahashi Y, Imoto M*: Novel derivatives of aclacinomycin A block cancer cell migration through inhibition of farnesyl transferase.
Journal of Antibiotics 66: 165-170, 2013.
Kato Y#, Kaneko N#, Sawada M#, Ito K, Arakawa S, Murakami S, Sawamoto K*: A subtype-specific critical period for neurogenesis in the postnatal development of mouse olfactory glomeruli.
PLoS One 7: e48431, 2012.
Nakaguchi K#, Jinnou H#, Kaneko N, Sawada M, Hikita T, Saitoh S, Tabata Y, Sawamoto K*: Growth factors released from gelatin hydrogel microspheres increase new neurons in the adult mouse brain.
Stem Cells International 2012: 915160, 2012.
Hirota Y, Sawada M, Kida YS, Huang S, Yamada O, Sakaguchi M, Ogura T, Okano H, Sawamoto K*: Roles of planar cell polarity signaling in maturation of neuronal precursor cells in the postnatal mouse olfactory bulb.
Stem Cells 30: 1726-1733, 2012.
Kobayashi H, Ogura Y, Sawada M, Nakayama R, Takano K, Minato Y, Takemoto Y, Tashiro E, Watanabe H, Imoto M*: Involvement of 14-3-3 Proteins in the Second Epidermal Growth Factor-induced Wave of Rac1 Activation in the Process of Cell Migration.
Journal of Biological Chemistry 286: 39259-39268, 2011.
Sawada M, Kaneko N, Inada H, Wake H, Kato Y, Yanagawa Y, Kobayashi K, Nemoto T, Nabekura J, Sawamoto K*: Sensory input regulates spatial and subtype-specific patterns of neuronal turnover in the adult olfactory bulb.
Journal of Neuroscience 31:11587-11596, 2011.
Sawada M#, Kubo S#, Matsumura K, Takemoto Y, Kobayashi H, Tashiro E, Kitahara T, Watanabe H*, Imoto M*: Synthesis and anti-migrative evaluation of moverastin derivatives.
Bioorganic & Medicinal Chemistry Letters 21: 1385-1389, 2011.
英文総説論文 *corresponding authors
Kanzawa T, Nakajima C, Sawada M, Sawamoto K*: How Growth Cones Sense Extracellular Cues and Drive Neuronal Migration: Shared Mechanisms Between Growth Cones of Migrating Neurons and Axons
Bioessays 47: e70050, 2025.
Nakajima C, Sawada M, Sawamoto K*: Postnatal neuronal migration in health and disease.
Current Opinion in Neurobiology 66: 1-9, 2021.
Kaneko N, Sawada M, Sawamoto K*: Mechanisms of neuronal migration in the adult brain.
Journal of Neurochemistry 141: 835-847, 2017.
Sawada M, Matsumoto M, Sawamoto K*: Vascular regulation of adult neurogenesis under the physiological and pathological conditions.
Frontiers in Neuroscience 8: 53, 2014.
Sawada M, Sawamoto K*: Mechanisms of neurogenesis in the normal and injured adult brain.
Keio Journal of Medicine 62: 13-28, 2013.
和文総説論文 *corresponding authors
中島 徳彦, 澤田 雅人, 澤本 和延*: ニューロンの移動と再生を促進する足場.
月刊 細胞 55: 16-19, 2023.
豊田 貴一, 澤田 雅人, 澤本 和延*: 成体脳におけるニューロンの細胞死と再生.
医学のあゆみ 283: 23433-23438, 2022.
榑松 千紘, 澤田 雅人, 澤本 和延*: ミクログリアによる成体新生ニューロンのシナプス刈り込みはホスファチジルセリンに依存する.
臨床免疫・アレルギー科 78: 703-708, 2022.
澤田 雅人, 澤本 和延*: 生後脳におけるニューロン移動の調節機構.
生化学 91: 178-190, 2019.
澤田 雅人, 澤本 和延*: ニューロンの移動停止過程で形成される突起.
神経化学トピックス doi: 10.11481/topipcs94, 2019.
荻野 崇, 岡田 洋平, 澤田 雅人, 澤本 和延*: 精神・神経疾患特異的 iPS 細胞を用いた創薬研究.
Annual Review 神経 2017: 68-73, 2017.
坪井 義晃, 澤田 雅人, 大塚 隆信, 澤本 和延*: 脳細胞の移動・再生促進技術の開発.
Drug Delivery System 32: 46-49, 2017.
澤田 雅人, 澤本 和延*: 成体脳における神経細胞死と再生の生体イメージング.
実験医学 34: 1095-1100, 2016.
澤本 和延*, 松本 真実, 澤田 雅人: 成体ニューロン新生における血管の役割.
生体の科学 65: 215-219, 2014.
澤田 雅人*: 感覚入力による成体嗅球ニューロンのターンオーバーの制御機構.
Nagoya Medical Journal 53: 63-68, 2013.
澤田 雅人, 澤本 和延*: 上衣細胞.
脳科学辞典 doi: 10.14931/bsd.2898, 2013.
澤本 和延*, 神農 英雄, 澤田 雅人, 齋藤 伸治: 新生児神経疾患の再生医療の可能性.
Fetal & Neonatal Medicine 4: 30-33, 2012.
英文著書 *corresponding authors
Sawada M, Sawamoto K*: Neuronal migration in the postnatal brain.
In: Comprehensive Developmental Neuroscience: Cellular migration and formation of axons and dendrites (Second edition, Elsevier), 465-478, 2020.
Sawada M, Huang SH, Hirota Y, Kaneko N, Sawamoto K*: Neuronal migration in theadult brain.
In: Neurogenesis in the adult brain I (Springer), 337-356, 2011.